David L. Tierney
Physical Inorganic and Bioinorganic Chemistry



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59. D. L. Tierney “XAS of Dinuclear Hydrolases” in Handbook of Binuclear Metallohydrolases: Structure, Function, Mechanism and Applications, G. Schenk and L. Gahan, Eds., 2013, in press.

58. A. Mousavi, A. R. Marts, D. L. Tierney and S. Cabaniss “Geometry of Zn(II) Complexes with Dissolved Organic Matter: X-Ray Studies at Variable pH” Tox. Environ. Chem., 2013, 95, 338-44.

57. D. L. Tierney “Jahn-Teller Dynamics in a Series of High-Symmetry Co(II) Chelates Determine Paramagnetic Relaxation Enhancements” J. Phys. Chem. A, 2012, 116, 10959-10972.

56. K. Grubel, A. R. Marts, S. M. Greer, D. L. Tierney, C. J. Allpress, S. N. Anderson, B. J. Laughlin, R. C. Smith,A. M. Arif and L. M. Berreau “Photoinitiated Dioxygenase-Type Reactivity of Open-Shell 3d Divalent Metal Flavolonato Complexes” Eur. J. Inorg. Chem., 2012, 4750-4757.

55. D. L. Zimbler, T. M. Park, B. A. Arivett, S. M. Greer, T. M. Woodruff, D. L. Tierney and L. A. Actis “Stress Response and Virulence of the A. Baumannii NfuA Fe-S Scaffold Protein” J. Bacter., 2012, 194, 2884-2893.

54. H. Yang, M. Aitha, A. M. Hetrick, T. K. Richmond, D. L. Tierney and M. W. Crowder “Mechanistic and Spectroscopic Studies of Metallo-b-Lactamase NDM-1” Biochemistry, 2012, 51, 3839-3847.

53. R. M. Breece, L. Llarrull, M. Tioni, A. J. Vila and D. L. Tierney “X-Ray Absorption Spectroscopy of Metal Site Speciation in the Metallo-b-Lactamase BcII from Bacillus cereusJ. Inorg. Biochem., 2012, 111, 182-186.

52. M. P. Hensley, T. S. Gunasekera, J. A. Easton, T. K. Sigdel, S. A. Sugarbaker, L. Klingbeil, D. L. Tierney and M. W. Crowder “Characterization of Zn(II)-Responsive Ribosomal Proteins YkgM and L31 in E. coliJ. Inorg. Biochem., 2012, 111, 164-172.

51. S. N. Oseback, S. W. Shim, M. Kumar, S. M. Greer, S. R. Gardner, K. M. Lemar, P. DeGregory, E. T. Papish, D. L. Tierney, M. Zeller and G. P. A. Yap "Crowded Bis-Ligand Complexes of TtzPh, Me with First Row Transition Metals Rearrange Due to Ligand Field Effects: Structural and Electronic Characterization (Ttz Ph, Me = tris(3-phenyl-5-methyl-1,2,4-triazolyl)borate)" Dalton Trans., 2012, 41, 2774-2787.

50. M. P. Hensley, D. L. Tierney and M. W. Crowder “Zn(II) Binding to E. coli 70S Ribosomes” Biochemistry, 2011, 50, 9937-9939.

49. D. H. Griffin, T. K. Richmond, C. Sanchez, A. J. Moller, R. M. Breece, D. L. Tierney, B. Bennett and M. W. Crowder “Structural and Kinetic Studies on Metallo-b-Lactamase IMP-1” Biochemistry, 2011, 50, 9125-9134.

48. J. K. Angelosante, L. M. Schopp, B. J. Lewis, A. D. Vitalo, D. T. Titus, R. A. Swanson, A. N. Stanley, B. P. Abolins, M. J. Frome, L. E. Cooper, D. L. Tierney, C. Moore, A. L. Rheingold and C. J. A. Daley “Synthesis and Characterization of an Unsymmetrical Cobalt(III) Active Site Analogue of Nitrile Hydratase” J. Biol. Inorg. Chem., 2011, 16, 937-947.

47. A. R. Marts, S. M. Greer, D. R. Whitehead, T. M. Woodruff, R. M. Breece, S. W. Shim, S. N. Oseback, E. T. Papish, F. E. Jacobsen, S. M. Cohen and D. L. Tierney “Dual Mode EPR Studies of a Kramers Ion: High-Spin Co(II) in 4-, 5- and 6-Coordination” Appl. Mag. Res., 2011, 40, 501-511.

46. P. S. Mariano, Z. Li, Z. Liu, D. W. Cho, J. Zou, M. Gong, R. M. Breece, A. Galkin, L. Li, H. Zhao, G. D. Maestas, D. L. Tierney, O. Herzberg and D. Dunaway-Mariano “Rational Design, Synthesis and Evaluation of First Generation Inhibitors of the Giardia lamblia Fructose-1,6-biphosphate Aldolase” J. Inorg. Biochem., 2011, 105, 509-517.

45. L. M. Berreau, T. Borowski, K. Grubel1, C. J. Allpress, J. P. Wikstrom, M. E. Germain, E. V. Rybak-Akimova and D. L. Tierney “Mechanistic Studies of the O2-dependent Aliphatic Carbon-carbon Bond Cleavage Reaction of a Nickel Enolate Complex” Inorg. Chem., 2011, 50, 1047-1057.

44. K. Linenberger, S. Lowery Bretz, M. W. Crowder, R. McCarrick, G. A. Lorigan and D. L. Tierney “What is Fresh Meat’s True Color? A Biophysical Undergraduate Laboratory Investigating the Effects of Ligand Binding on Myoglobin Using Optical, Electron Paramagnetic Resonance and Nuclear Magnetic Resonance Spectroscopies” J. Chem. Ed., 2011, 88, 223-225.

43. F. Xie, D. V. Zaytsev, M. Mukherjee, A. Bludin, B. Demeler, R. M. Breece, D. L. Tierney and M. Y. Ogawa “Nanometer to Millimeter-Scale Peptide-Porphyrin Materials” Biomacromolecules, 2010, 11, 2602-2609.

42. V. A. Campos-Bermudez, J. M. Gonzalez, D. L. Tierney and A. J. Vila “Spectroscopic Signature of a Ubiquitous Metal Binding Site in the Metallo-b-Lactamase Superfamily” J. Biol. Inorg. Chem., 2010, 15, 1209-1218.

41. E. M. Stone, E. S. Glazer, L. Chantranupong, P. Cherukuri, R. M. Breece, D. L. Tierney, S. A. Curley, B. L. Iverson and G. Georgiou “Replacing Mn2+ with Co2+ in Human Arginase I Enhances Cytotoxicity Towards L-Arginine Auxotrophic Cancer Cell Lines” ACS Chem. Biol., 2010, 5, 333-342.

40. R. M. Breece, Z. Hu, B. Bennett, M. W. Crowder and D. L. Tierney “Motion of the Zinc Ions in Catalysis by a di-Zinc Metallo-b-Lactamase” J. Am. Chem. Soc., 2009, 131, 11642-11643.

39. W. K. Myers, C. P. Scholes and D. L. Tierney “Anisotropic Fermi Couplings due to Large Unquenched Orbital Angular Momentum: Q-Band 1H, 14N and 11B ENDOR of Bistrispyrazolylborate Co(II)” J. Am. Chem. Soc., 2009, 131, 10421-10429.

38. M. J. Hawk, R. M. Breece, C. E. Hajdin, K. M. Bender, Z. Hu, A. L. Costello, B. Bennett, D. L. Tierney and M. W. Crowder “Differential Binding of Co(II) and Zn(II) to Metallo-b-lactamase Bla2 from Bacillus anthracisJ. Am. Chem. Soc., 2009, 131, 10753-10762.

37. V. S. Thoi, J. L. Stork, E. T. Niles, E. C. Depperman, D. L. Tierney and S. M. Cohen “Diamidodipyrrins: Versatile Bipyrrolic Ligands with Multiple Binding Modes” Inorg. Chem., 2008, 47, 10533-10541.

36. L. A. Abriata, L. J. Gonzalez, L. I. Llarrull, P. E. Tomatis, W. K. Myers, A. L. Costello, D. L. Tierney and A. J. Vila “Engineered Mononuclear Variants in Bacillus cereus Metallo-b-lactamase BcII are Inactive” Biochemistry, 2008, 47, 8590-8599.

35. W. K. Myers, E. N. Duesler and D. L. Tierney “Integrated Paramagnetic Resonance of High-Spin Co(II) in Axial Symmetry: Chemical Separation of Dipolar and Contact Electron-Nuclear Couplings” Inorg. Chem., 2008, 47, 6701-6710.

34. H. Maeda, D. L. Tierney, P. S. Mariano, M. Bannerjee, D. W. Cho and U. C. Yoon “Lariat-Crown Ether Based Fluorescence Sensors for Heavy Metal Ions” Tetrahedron, 2008, 64, 5268-5278.

33. L. A. Yatsunyk, J. A. Easton, L. R. Kim, S. A. Sugarbaker, B. Bennett, R. M. Breece, I. I. Vorontsov, D. L. Tierney, M. W. Crowder and A. C. Rosenzweig “Structure and Metal binding Properties of ZnuA, a Periplasmic Zinc Transporter from Eschericia coliJ. Biol. Inorg. Chem., 2008, 13, 271-288.

32. A. R. Reddi, T. R. Guzman, R. M. Breece, D. L. Tierney and B. R. Gibney “Deducing the Energetic Cost of Protein Folding in Zinc Finger Proteins Using Designed Metallopeptides” J. Am. Chem. Soc., 2007, 129, 12815-12827.

31. J. M. Gonzalez, F. J. Medrano, A. L. Costello, D. L. Tierney and A. J. Vila “The Zn2 Position in Metallo-b-Lactamases is Critical for Activity: A Study of Chimeric Metal Sites on a Conserved Protein Scaffold” J. Mol. Biol., 2007, 373, 1141-1156.

30. J. M. Barrio, J. M. Gonzalez, M. N. Lisa, A. L. Costello, M. del Peraro, P. Carloni, B. Bennett, D. L. Tierney, A. S. Limansky, A. M. Viale and A. J. Vila “The Metallo-b-Lactamase GOB is a Mono-Zn(II) Enzyme with a Novel Active Site” J. Biol. Chem., 2007, 282, 18286-18293.

29. E. A. Riley, A. K. Petros, K. A. Smith, B. R. Gibney and D. L. Tierney “Frequency-Switching Inversion-Recovery for Severely Hyperfine Shifted NMR: Evidence of Asymmetric Electron Relaxation in High-Spin Co(II)” Inorg. Chem., 2006, 45, 10016-10018.

28. R. M. Franzini, R. M. Watson, G. K. Patra, R. M. Breece, D. L. Tierney, M. P. Hendrich and C. Achim “Metal Binding to Bipyridine-Modified PNA Duplexes” Inorg. Chem., 2006, 45, 9798-9811.

27. A. L. Costello, N. P. Sharma, K.-W. Yang, M. W. Crowder and D. L. Tierney “X-Ray Absorption Spectroscopy of the Zinc Binding Sites in the Class B2 Metallo-b-Lactamase ImiS from Aeromonas veronii bv. sobriaBiochemistry, 2006, 45, 13650-13658.

26. J. Momb, P. W. Thomas, R. M. Breece, D. L. Tierney and W. Fast “The Quorum-Quenching Metallo-g- Lactonase from Bacillus thuringiensis Exhibits a Leaving Group Thio Effect” Biochemistry, 2006, 45, 13385-13393.

25. F. E. Jacobsen, R. M. Breece, W. K. Myers, D. L. Tierney, and S. M. Cohen “Model Complexes of Cobalt-Substituted Matrix Metalloproteinases: Tools for Inhibitor Design” Inorg. Chem., 2006, 45, 7306-7315.

24. E. M. Stone, A. L. Costello, D. L. Tierney, and W. Fast “Substrate-Assisted Cysteine Deprotonation in the Mechanism of Dimethylargininase (DDAH) from Pseudomonas aeruginosaBiochemistry, 2006, 45, 5618-5630.

23. A. L. Costello, G. Periyannan, K.-W. Yang, M. W. Crowder and D. L. Tierney “Site Selective Binding of Zn(II) to Metallo-b-Lactamase L1 from Stenotrophomonas maltophiliaJ. Biol. Inorg. Chem., 2006, 11, 351-358.

22. G. Periyannan, A. L. Costello, D. L. Tierney, K.-W. Yang, B. Bennett and M. W. Crowder “Sequential Binding of Cobalt(II) to Metallo-b-Lactamase CcrA” Biochemistry, 2006, 45, 1313-1320.

21. A. V. Ellis, C. F. M. Clewett, D. L. Tierney, J. L. Dewald, S. A. Curran and T. Pietraß “Electron Spin Resonance and Raman Scattering Spectroscopy of Multi-Walled Carbon Nanotubes: A Function of Acid Treatment” J. Nanosci. Nanotech., 2006, 6, 135-140.

20. P. W. Thomas, E. M. Stone, A. L. Costello, D. L. Tierney and W. Fast “The Quorum-Quenching Lactonase from Bacillus thuringiensis Is a Metalloprotein” Biochemistry, 2005, 44, 7559-7569.

19. R. M. Breece, A. L. Costello, B. Bennett, T. K. Sidgel, M. L. Mathews, D. L. Tierney and M. W. Crowder “A Five-Coordinate Metal Site in VanX” J. Biol. Chem., 2005, 280, 11074-11081.

18. D. L. Tierney, A. M. Rocklin, J. D. Lipscomb, L. Que, Jr. and B. M. Hoffman “ENDOR Studies of the Ligation and Structure of the Non-Heme Iron Site in ACC Oxidase” J. Am. Chem. Soc., 2005, 127, 7005-7013.

17. A. K. Petros, S. E. Shaner, A. L. Costello, D. L. Tierney and B. R. Gibney “Comparison of Cysteine and Penicillamine Ligands in a Co(II) Maquette” Inorg. Chem., 2004, 43, 4793-4795.

16. K. Shen, D. L. Tierney and T. Pietraß “Electron Spin Resonance of Carbon Nanotubes Under Hydrogen Adsorption” Phys. Rev. B, 2003, 68, 165418.

15. M. Carepo, D. L. Tierney, C. D. Brondino, T. C. Yang, A. Pamplona, J. Telser, I. Moura, J. J. G. Moura and B. M. Hoffman “17O ENDOR Detection of a Solvent-Derived Ni-(OHx)-Fe Bridge That is Lost Upon Activation of the Hydrogenase from Desulfovibrio gigasJ. Am. Chem. Soc., 2002, 124, 281-286.

14. D. L. Tierney, P. J. Moehs, and D. L. Hasha “1,3-Dichloro- and 1,3-Dibromotetra-n-butyldistannoxane Mixtures: Ligand Redistribution and Fluxional Dynamics in Distannoxanes” J. Organomet. Chem., 2001, 620, 211-226.

13. D. L. Tierney, H. Huang, P. Martasek, L. Roman, B. S. S. Masters, B. M. Hoffman and R. B. Silverman “ENDOR Spectroscopic Evidence for the Geometry of Binding of retro-inverso-Nw-Nitroarginine-Containing Dipeptide Amides to Neuronal Nitric Oxide Synthase” J. Am. Chem. Soc., 2000, 122, 7869-7875.

12. D. L. Tierney, H. Huang, P. Martasek, L. Roman, B. S. S. Masters, R. B. Silverman and B. M. Hoffman “ENDOR Studies of L-Arginine and NG-Hydroxy-L-Arginine Bound to all Three Holo-Nitric Oxide Synthase Isozymes” J. Am. Chem. Soc., 2000, 122, 5405-5406.

11. D. L. Tierney, G. T. Gassner, C. Luchinat, I. Bertini, D. P. Ballou and J. E. Penner-Hahn “NMR Characterization of Substrate Binding in the Phthalate Dioxygenase System” Biochemistry, 1999, 38, 11051-11061.

10. A. M. Rocklin, D. L. Tierney, V. Kofman, N. M. W. Brunhuber, B. M. Hoffman, R. E. Christoffersen, N. O. Reich, J. D. Lipscomb and L. Que, Jr. “Role of the Nonheme Fe(II) Center in the Biosynthesis of the Plant Hormone Ethylene” Proc. Natl. Acad. Sci., 1999, 96, 7905-7909.

  9. D. L. Tierney, H. Huang, P. Martasek, B. S. S. Masters, R. B. Silverman and B. M. Hoffman “ENDOR Spectroscopic Evidence for the Position and Structure of NG-Hydroxy-L-Arginine Bound to Holo-Neuronal Nitric Oxide Synthase” Biochemistry, 1999, 38, 3704-3710.

  8. K. Clark-Baldwin, D. L. Tierney, K. Govindaswamy, E. Gruff, C. W. Kim, J. M. Berg, S. A. Koch and J. E. Penner-Hahn “The Limitations of X-Ray Absorption Spectroscopy for Determining the Structure of Zinc Sites in Proteins: When is a Tetrathiolate not a Tetrathiolate?” J. Am. Chem. Soc., 1998, 120, 8401-8409.

  7. D. L. Tierney, P. Martasek, P. E. Doan, B. S. S. Masters and B. M. Hoffman “Location of Guanidino Nitrogen of L-Arginine Substrate Bound to Neuronal Nitric Oxide Synthase (nNOS): Determination by Q-band Pulsed ENDOR Spectroscopy” J. Am. Chem. Soc., 1998, 120, 2983-2984.

  6. G. R. Dieckmann, D. L. Tierney, L. M. Utshcig, D. K. McRorie, T. V. O'Halloran, J. E. Penner-Hahn, W. F. DeGrado and V. L. Pecoraro “The de novo Design of Mercury Binding Two- and Three-Helical Bundles” J. Am. Chem. Soc., 1997, 119, 6195-6196.

  5. G. A. Garcia, D. L. Tierney, S. Chong, K. Clark and J. E. Penner-Hahn “X-Ray Absorption Spectroscopy of the Zinc Site in tRNA-Guanine Transglycosylase from Eschericia coliBiochemistry, 1996, 35, 3133-3139.

  4. R. T. Witkowski, K. Clark, D. L. Tierney, J. E. Penner-Hahn, L. Newman, S. Hattman and G. McLendon “The Zinc Coordination Site of the Bacteriophage Mu Translation Activating Protein Com” J. Mol. Biol., 1995, 247, 753-764.

  3. D. L. Tierney, J. A. Fee, M. L. Ludwig and J. E. Penner-Hahn “X-Ray Absorption Spectroscopy of the Iron Site in E. coli Fe(III) Superoxide Dismutase” Biochemistry, 1995, 34, 1661-1668.

  2. J. A. Landro, E. Schmidt, P. Schimmel, D. L. Tierney and J. E. Penner-Hahn “Thiol Ligation of Two Zinc Atoms to a Class I tRNA Synthetase: Evidence for Unshared Thiols and Role in Amino Acid Binding and Utilization” Biochemistry, 1994, 33, 14213-14220.

  1. M. S. Lah , B. R. Gibney, D. L. Tierney, J. E. Penner-Hahn and V. L. Pecoraro “The Fused Metallacrown Anion Na2([Na0.5[Ga(salicylhydroximate)]4]2(m2-OH)4)- is an Inorganic Analog of a Cryptate” J. Am. Chem. Soc., 1993, 115, 5857-5858.